- Title
- Association of Topical Corticosteroids with Reduced Vulvar Squamous Cell Carcinoma Recurrence in Patients with Vulvar Lichen Sclerosus
- Creator
- Chin, Simone; Scurry, James; Bradford, Jennifer; Lee, Geoffrey; Fischer, Gayle
- Relation
- JAMA Dermatology Vol. 156, Issue 7, p. 813-814
- Publisher Link
- http://dx.doi.org/10.1001/jamadermatol.2020.1074
- Publisher
- American Medical Association
- Resource Type
- journal article
- Date
- 2020
- Description
- Vulvar lichen sclerosus (vLS), if untreated, results in a 5% to 7% increased lifetime incidence of vulvar squamous cell carcinoma (vSCC) and differentiated vulvar intraepithelial neoplasia (dVIN). This incidence rate can be reduced by suppressive topical corticosteroid treatment; however, whether topical corticosteroid therapy can also reduce the rate of vSCC recurrence remains unknown. Current data report a 5-year rate of recurrence of 44% to 47% after surgical treatment. Furthermore, if a patient had 1 recurrence, their chance of another recurrence within 5 years rises to 80%. Determining whether topical corticosteroid treatment after surgery can reduce the risk of recurrence is important because up to 25% of women with vLS report not being treated with topical corticosteroid after vSCC excision. If shown to have an association with preventing cancer recurrence, topical corticosteroid therapy could be readily implemented.
- Subject
- topical corticosteroids; vulvar squamous cell carcinoma; vulvar lichen sclerosus; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1446724
- Identifier
- uon:42952
- Identifier
- ISSN:2168-6068
- Language
- eng
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